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Semler Research - Formulation Development

Semler Research Center
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Product Description:
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Preclinical Formulation Development.

- Analytical Development: Assay and relative substance method development based on already existing drug substance methods with partial validation to perform the preformulation studies.
- Physico chemical evaluation, solubility studies: pH dependent aqueous solubility, solubility studies in alcohols and polyols solvents, solubility in co-solvents and surfactant assisted solubility
- Inherent dissolution study in various pH conditions
- Salt design/screening and selection
- Dissociation constant redetermination
- Partition coefficient and log P determination
- Polymorphism study
- Particle size, surface area, bulk/tapped density determination
- Stability study: Solution stability, pH depended solubility, process equipment compatibility study, filter compatibility study, solid state stability, stress stability, photo stability, accelerated stability study as per ICH guidelines
- Dynamic moisture absorption study
- Drug excipients interaction study in solution form
- Preclinical formulation
- Stability study of preclinical formulation
- Closure container compatibility study

Equipment

- Multi Station Tablet Press (D & B Tooling with instrumentation)
- V blender
- Planetary Mixture
- High Speed Mixture and Granulator
- Dry Granulator
- Pan Coater
- USP dissolution Apparatus with auto sampler
- Tablet: USP Hardness Tester, USP Disintegrator and USP Friability Tester
- Stability Chambers (Complies with ICH Guidelines)
- HPLC (Waters Alliance 2695) with PDA Detector
- Differential Scanning Calorimetry (Shimadzu)
- FTIR (Shimadzu)
- Thermo Gravimetric Analyzer (TGA) (Shimadzu)
- UV-Vis Spectrophotometer
- Moisture Analyzer
- Diffusion Cells, For Permeation Studies
- Cell Culture Facilty for Permeation Studies using Caco2 and MDCK Cell Lines.
Other Details:

Offered by: Semler Research Center (View Showroom, Create your own Showroom)
Place of Origin: India (More Products from India)
Stock Location: India
Quantity: Not Specified
Packaging: Not Specified
Price: Not Specified
Product Seller Classification: Services - Other Business Services
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